Pieter Neefs was a painter of architectural compositions and began his career as a pupil of Hendrick van Steenwyck. In 1609 he entered the Guild of Antwerp and in 1612 he married Maria Lauterbeens. Their son, Pieter Neefs the Younger, became a pupil of his father and went on to become a well-known painter in his own right.

The majority of Pieter Neefs' compositions were based on Churches and Cathedrals in Antwerp and he is reknowned for his accuracy in depicting architectural detail. He often collaborated with other artists, supplying the architectural settings in which they placed their figures. These artists included Jan Brueghel the Elder, Sebastian Vrancx, Adriaen van Stalbempt and David Teniers.


Museums where examples of the artist's work can be found include:
Aix, Amsterdam (Rijksmuseum), Bonn, Cambridge and Moscow