Job Adriaensz Berckheyde has become one of the most important painters of architectural interiors in Seventeenth Century Holland, along with Pieter Saenredam whose work he greatly admired. In 1644, at the young age of 14 he was apprenticed to Jacob Willemsz de Wet and his early paintings show the Rembrandtesque influence of his Master. He became a member of the Guild of Haarlem in 1654. Berckheyde travelled to Germany with his brother, staying mostly in Heidelberg but visiting Cologne, Bonn and Mannheim. He was his brother's teacher and it is generally accepted that Job was the more precocious and gifted of the two. His subtle use of light and shadow is more reminiscent of Saenrendam than de Wet and his eye for architectural detail along with his expansive understanding of perspectoral depth meant he became enormously successful in his own lifetime. He worked a great deal for the Elector Palatine, who was also to employ his younger brother. A self portrait of c.1655 (Frans Halsmuseum, Haarlem) depicts him wearing a gold chain given to him by the Elector.

Job Adriaensz Berckheyde is known to have painted a number of other compositions including portraits, hunting scenes and genre subjects in the style of Adriaen Ostade and Jan Steen but it is for his subtely lit architectural paintings that he is best known.

Museums where examples of the artist's work can be found include:
Amsterdam, Brussels, Kassel, Dresden, Frankfurt, Haarlem, St. Petersburg, New York, Rotterdam, Schwerin, and Venice